Stellingen
Behorende bij het
proefschrift
- The rate constants of
metabolic lipolysis and uptake processes affecting apoB-containing
lipoproteins can be expressed as a continuous function of lipoprotein
particle size (Chapter 2).
- The model-based diagnostic
'VLDL performance' efficiently distinguishes normolipidemic from
dyslipidemic subjects (Chapter 3).
- The difference in lipoprotein
metabolism after medium chain fatty acid versus C18:2n-6 supplementation
is consistent with the mechanism of PPAR activation due to the latter
fatty acid (Chapter 4).
- The ‘extrahepatic lipolysis
ratio’ and the ‘hepatic turnover ratio’ of VLDL metabolism improve
cardiovascular risk prediction when added to a multivariate model
including classical and NMR-based risk markers (Chapter 6).
- The Net Reclassification
Index is a sensitive and clinically relevant statistic for comparison of
diagnostics (see Pencina et al 2009,
Stat Med).
- Comparing different
lipoprotein profile measurement methods is made difficult both by
differences in the particle size definition and by differences in the
subclass size range definition (see
Otvos et al. 1999, Clin Chem; Usui et al. 2002, J Lipid Res).
- Overproduction of large VLDL
particles is driven by liver fat content rather than by liver cholesterol
content (see Adiels et al. 2006,
Diabetologia).
- So far the only useful
alternative to LDL cholesterol and HDL cholesterol diagnostics derived
from detailed lipoprotein profiles are LDL and HDL particle number, that
use little of the detailed size information contained in the profile (see Cromwell et all, 2007, J Clin
Lipidol).
- Systematic reflection about
the fact that the universe develops along the road of natural laws reveals
the presence of a living spirit, a 'Road Worker'.
- Working time and facilities
are essential for innovation, but above all it requires the scientist’s
free choice to pursue the practical application of the new idea.
- A new human organism comes into
being at the very moment of fertilization of a human ovule, when all
relevant genes and systems for development are in place.
- What an affectionate greeting
does communicate, no mathematical model can relate.
Note: At Leiden University, it is customary that the PhD candidate presents twelve 'stellingen' that he is willing to discuss during the public defence of his PhD thesis. The first four concern the PhD thesis itself, the second four the scientific literature of the corresponding field, and the last four are freely electable. All should be defensible with reasoned arguments.
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